Thesis
Innate sensing of bacterial flagellin in acute and chronic intestinal inflammation
- Abstract:
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Flagellin is a highly immunogenic, bacterial protein considered to be abundant in the intestinal lumen. It has been reported to be an immunodominant antigen in patients with inflammatory bowel disease (IBD). In the work presented in this thesis several complementary murine models of IBD were employed to elucidate the role of innate immune sensing of flagellin in the development of intestinal inflammation. Pattern recognition receptors (PRRs) enable mammals to discriminate self from non-sel...
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Bibliographic Details
- Publication date:
- 2013
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- Oxford University, UK
Item Description
- Language:
- English
- Keywords:
- Subjects:
- UUID:
-
uuid:775c4150-9b22-4008-9288-3a6053cbf4cc
- Local pid:
- ora:11402
- Deposit date:
- 2015-05-08
Terms of use
- Copyright holder:
- Nordlander, S
- Copyright date:
- 2014
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