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Thesis

Protein based molecular probes by unnatural amino acid incorporation

Abstract:

The "tag & modify" strategy for protein modification relies upon the genetic incorporation of an uncommon or unnatural amino acid into a protein backbone, followed by a chemo-selective modification to yield differentially modified proteins. This thesis describes the creation of a protein-based glycoconjugate tool for interrogating biological function.

In Chapter 2, the unnatural amino acid, azidohomoalanine was genetically incorporated into a library of distance defined Np276 pr...

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Department:
Oxford, MPLS, Chemistry, Organic Chemistry
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Author

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Department:
Oxford Chemistry
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Supervisor
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Funding agency for:
Peter Crane
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
Language:
English

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