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Investigating TDP43 biological dysfunction through the characterisation of Tardbp ENU mouse mutants: implications for neurodegeneration

Abstract:

TDP43 is a highly conserved ubiquitously expressed protein which performs multiple roles in RNA metabolism, including regulation of gene expression, pre-mRNA splicing and the regulation of micro-RNA biogenesis. It belongs to the hnRNP family and interacts extensively with other proteins and RNA to perform its known biological functions and, analogously to other proteins from the same family, is proposed to autoregulate its own protein levels.

TDP43 biological dysfunction plays a piv...

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Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Oxford college:
Wolfson College
Role:
Author
More by this author
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author

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Role:
Supervisor
Role:
Supervisor
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Funding agency for:
De Sao Jose Martinho De Oliveira, H
Publication date:
2014
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
Oxford University, UK

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