Journal article
LGI1, CASPR2 and related antibodies: a molecular evolution of the phenotypes
- Abstract:
-
Recent biochemical observations have helped redefine antigenic components within the voltage-gated potassium channel (VGKC) complex. The related autoantibodies may be now divided into likely pathogenic entities, which target the extracellular domains of leucine-rich glioma-inactivated 1 (LGI1) and contactin-associated protein 2 (CASPR2), and species that target intracellular neuronal components and are likely non-pathogenic. This distinction has enhanced clinical practice as direct determinat...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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Authors
Funding
UCB – Oxford University Alliance
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British Medical Association
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Epilepsy Research UK
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Fulbright UK–US commission
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Bibliographic Details
- Publisher:
- BMJ Publishing Group Publisher's website
- Journal:
- Journal of Neurology, Neurosurgery and Psychiatry Journal website
- Volume:
- 89
- Pages:
- 526-534
- Publication date:
- 2017-10-21
- Acceptance date:
- 2017-09-22
- DOI:
- EISSN:
-
1468-330X
- ISSN:
-
0022-3050
Item Description
- Pubs id:
-
pubs:733033
- UUID:
-
uuid:75a810d9-0122-495d-8b3c-a2a73f113df5
- Local pid:
- pubs:733033
- Deposit date:
- 2017-10-06
Terms of use
- Copyright holder:
- Irani et al
- Copyright date:
- 2017
- Notes:
- © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2017. All rights reserved. No commercial use is permitted unless otherwise expressly granted. This is an Open Access article distributed in accordance with the terms of the Creative Commons Attribution (CC BY 4.0) license, which permits others to distribute, remix, adapt and build upon this work, for commercial use, provided the original work is properly cited. See: http://creativecommons.org/licenses/by/4.0/
- Licence:
- CC Attribution (CC BY)
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