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Thesis

Replication catastrophe induced by cyclic hypoxia leads to increased APOBEC3B activity

Abstract:

Regions of low oxygen (hypoxia) occur in most human solid tumours and correlate with a poor patient prognosis as hypoxic regions are resistant to most cancer therapies and have an increased metastatic potential. Hypoxia is a highly dynamic state, characterised by oxygen fluctuations on the order of minutes, hours, and days occurring simultaneously in regions throughout the tumour. Dynamic changes in tumour oxygenation are referred to as “cyclic hypoxia” that can span a wide range of oxygen...

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Institution:
University of Oxford
Division:
MSD
Department:
Oncology
Subgroup:
CRUK/MRC Ox Inst for Radiation Oncology
Research group:
ORCRB
Oxford college:
Wolfson College
Role:
Author

Contributors

Institution:
University of Oxford
Division:
MSD
Department:
Oncology
Subgroup:
CRUK/MRC Ox Inst for Radiation Oncology
Oxford college:
St Hilda's College
Role:
Supervisor
ORCID:
0000-0002-2335-3146
More from this funder
Grant:
C5255/A23755
Funding agency for:
Hammond, E
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford

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