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BAT117213: Ileal bile acid transporter (IBAT) inhibition as a treatment for pruritus in primary biliary cirrhosis: study protocol for a randomised controlled trial

Abstract:

Background Pruritus (itch) is a symptom commonly experienced by patients with cholestatic liver diseases such as primary biliary cholangitis (PBC, previously referred to as primary biliary cirrhosis). Bile acids (BAs) have been proposed as potential pruritogens in PBC. The ileal bile acid transporter (IBAT) protein expressed in the distal ileum plays a key role in the enterohepatic circulation of BAs. Pharmacological inhibition of IBAT with GSK2330672 may reduce BA levels ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1186/s12876-016-0481-9

Authors


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Role:
Author
ORCID:
0000-0002-0804-5743
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDORMS
Sub department:
Botnar Research Centre
Oxford college:
St Hilda's College
Role:
Author
ORCID:
0000-0002-8093-7084
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GlaxoSmithKline More from this funder
Publisher:
BioMed Central Publisher's website
Journal:
BMC Gastroenterology Journal website
Volume:
16
Issue:
1
Article number:
71
Publication date:
2016-07-19
Acceptance date:
2016-06-14
DOI:
EISSN:
1471-230X
Pmid:
27431238
Source identifiers:
1033429

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