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Journal article

Memory B cell response to a PCV-13 booster in 3.5year old children primed with either PCV-7 or PCV-13.

Abstract:

Pneumococcal protein-polysaccharide conjugate vaccines provide direct protection against Streptococcus pneumoniae through the induction of persistent anti-polysaccharide antibodies, and by priming for a rapid secondary antibody response. Memory B cells (BMEM) generated during an initial immune response are responsible for both the more rapid and quantitatively greater secondary antibody response and are also thought to contribute to the ongoing production of plasma cells providing long-term a...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.vaccine.2017.03.079

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Paediatrics
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Paediatrics
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Paediatrics
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Primary Care Health Sciences
Role:
Author
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More from this funder
Funding agency for:
Trück, J
Grant:
Fellowship Award
Pfizer Vaccine Research More from this funder
University of Oxford More from this funder
National Institute for Health Research More from this funder
Publisher:
Elsevier Publisher's website
Journal:
Vaccine Journal website
Volume:
35
Issue:
20
Pages:
2701-2708
Publication date:
2017-04-01
Acceptance date:
2017-03-29
DOI:
ISSN:
1873-2518
Source identifiers:
689218
Language:
English
Keywords:
Pubs id:
pubs:689218
UUID:
uuid:7554eb7e-1e41-4cbe-86f8-2c8ffd391657
Local pid:
pubs:689218
Deposit date:
2017-04-18

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