Constrained pattern of viral evolution in acute and early HCV infection limits viral plasticity.
Cellular immune responses during acute Hepatitis C virus (HCV) and HIV infection are a known correlate of infection outcome. Viral adaptation to these responses via mutation(s) within CD8+ T-cell epitopes allows these viruses to subvert host immune control. This study examined HCV evolution in 21 HCV genotype 1-infected subjects to characterise the level of viral adaptation during acute and early HCV infection. Of the total mutations observed 25% were within described CD8+ T-cell epitopes or ...Expand abstract
- Publication status:
- Copyright holder:
- Pfafferott et al.
- Copyright date:
- Copyright 2011 Pfafferott et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Views and Downloads
If you are the owner of this record, you can report an update to it here: Report update to this record