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High-resolution 3D imaging uncovers organ-specific vascular control of tissue aging

Abstract:

Blood vessels provide supportive microenvironments for maintaining tissue functions. Age-associated vascular changes and their relation to tissue aging and pathology are poorly understood. Here, we perform 3D imaging of young and aging vascular beds. Multiple organs in mice and humans demonstrate an age-dependent decline in vessel density and pericyte numbers, while highly remodeling tissues such as skin preserve the vasculature. Vascular attrition precedes the appearance of cellular hallmark...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1126/sciadv.abd7819

Authors


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Role:
Author
ORCID:
0000-0003-1717-5782
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Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Sub department:
Kennedy Institute for Rheumatology
Role:
Author
ORCID:
0000-0002-6074-6299
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Role:
Author
ORCID:
0000-0002-5911-0832
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Role:
Author
ORCID:
0000-0002-6116-4135
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John Fell Fund More from this funder
John Fell Fund More from this funder
Publisher:
American Association for the Advancement of Science Publisher's website
Journal:
Science Advances Journal website
Volume:
7
Issue:
6
Article number:
eabd7819
Publication date:
2021-02-03
Acceptance date:
2020-12-23
DOI:
EISSN:
2375-2548
Language:
English
Keywords:
Pubs id:
1160059
Local pid:
pubs:1160059
Deposit date:
2021-02-04

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