Journal article
TCF7L2 plays a complex role in human adipose progenitor biology, which might contribute to genetic susceptibility to type 2 diabetes
- Abstract:
-
Introduction Non-coding genetic variation at TCF7L2 is the strongest genetic determinant of type 2 diabetes (T2D) risk in humans. TCF7L2 encodes a transcription factor mediating the nuclear effects of WNT signaling in adipose tissue (AT). In vivo studies in transgenic mice have highlighted important roles for TCF7L2 in adipose tissue biology and systemic metabolism. Objective To map the expression of TCF7L2 in human AT, examine its role in human adipose cell biology in vitro, and investigate...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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Authors
Funding
Bibliographic Details
- Publisher:
- Elsevier Publisher's website
- Journal:
- Metabolism: clinical and experimental Journal website
- Volume:
- 133
- Article number:
- 155240
- Publication date:
- 2022-06-10
- Acceptance date:
- 2022-06-04
- DOI:
- ISSN:
-
0026-0495
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
1260035
- Local pid:
- pubs:1260035
- Deposit date:
- 2022-05-17
Terms of use
- Copyright holder:
- Verma et al.
- Copyright date:
- 2022
- Rights statement:
- © 2022 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
- Licence:
- CC Attribution (CC BY)
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