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The role of the Hes1 crosstalk hub in Notch-Wnt interactions of the intestinal crypt

Abstract:

The Notch pathway plays a vital role in determining whether cells in the intestinal epithelium adopt a secretory or an absorptive phenotype. Cell fate specification is coordinated via Notch's interaction with the canonical Wnt pathway. Here, we propose a new mathematical model of the Notch and Wnt pathways, in which the Hes1 promoter acts as a hub for pathway crosstalk. Computational simulations of the model can assist in understanding how healthy intestinal tissue is maintained, and predict ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1371/journal.pcbi.1005400

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Institution:
University of Oxford
Division:
MPLS
Department:
Computer Science
Role:
Author
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Institution:
University of Oxford
Oxford college:
St Cross College
Role:
Author
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Publisher:
Public Library of Science Publisher's website
Journal:
PLoS Computational Biology Journal website
Volume:
13
Issue:
2
Pages:
e1005400
Publication date:
2017-02-28
Acceptance date:
2017-02-07
DOI:
EISSN:
1553-7358
ISSN:
1553-734X
Source identifiers:
640679
Keywords:
Pubs id:
pubs:640679
UUID:
uuid:711e2c10-88b0-48e1-97bc-5a5e56d0d58e
Local pid:
pubs:640679
Deposit date:
2017-02-07

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