Journal article
The role of the Hes1 crosstalk hub in Notch-Wnt interactions of the intestinal crypt
- Abstract:
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The Notch pathway plays a vital role in determining whether cells in the intestinal epithelium adopt a secretory or an absorptive phenotype. Cell fate specification is coordinated via Notch's interaction with the canonical Wnt pathway. Here, we propose a new mathematical model of the Notch and Wnt pathways, in which the Hes1 promoter acts as a hub for pathway crosstalk. Computational simulations of the model can assist in understanding how healthy intestinal tissue is maintained, and predict ...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Version of record, pdf, 3.1MB)
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- Publisher copy:
- 10.1371/journal.pcbi.1005400
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Authors
Bibliographic Details
- Publisher:
- Public Library of Science Publisher's website
- Journal:
- PLoS Computational Biology Journal website
- Volume:
- 13
- Issue:
- 2
- Pages:
- e1005400
- Publication date:
- 2017-02-28
- Acceptance date:
- 2017-02-07
- DOI:
- EISSN:
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1553-7358
- ISSN:
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1553-734X
- Source identifiers:
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640679
Item Description
Terms of use
- Copyright holder:
- © 2017 Kay et al
- Copyright date:
- 2017
- Notes:
- © 2017 Kay et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
- Licence:
- CC Attribution (CC BY)
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