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Rituximab abrogates aquaporin-4-specific germinal center activity in patients with neuromyelitis optica spectrum disorders

Abstract:

Neuromyelitis optica spectrum disorders (NMOSDs) are caused by immunoglobulin G (IgG) autoantibodies directed against the water channel aquaporin-4 (AQP4). In NMOSDs, discrete clinical relapses lead to disability and are robustly prevented by the anti-CD20 therapeutic rituximab; however, its mechanism of action in autoantibody-mediated disorders remains poorly understood. We hypothesized that AQP4-IgG production in germinal centers (GCs) was a core feature of NMOSDs and could be terminated by...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1073/pnas.2121804119

Authors


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Role:
Author
ORCID:
0000-0003-1740-4522
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Institution:
University of Oxford
Division:
MSD
Department:
Psychiatry
Oxford college:
St Edmund Hall
Role:
Author
ORCID:
0000-0001-6596-7579
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Role:
Author
ORCID:
0000-0002-3082-9210
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Medical Research Council More from this funder
Publisher:
National Academy of Sciences Publisher's website
Journal:
Proceedings of the National Academy of Sciences Journal website
Volume:
119
Issue:
24
Article number:
e2121804119
Publication date:
2022-06-06
Acceptance date:
2022-04-04
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
Pmid:
35666871
Language:
English
Keywords:
Pubs id:
1262641
Local pid:
pubs:1262641
Deposit date:
2022-06-11

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