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Journal article

Saporin-conjugated tetramers identify efficacious anti-HIV CD8+ T-cell specificities.

Abstract:

Antigen-specific T-cells are highly variable, spanning potent antiviral efficacy and damaging auto-reactivity. In virus infections, identifying the most efficacious responses is critical to vaccine design. However, current methods depend on indirect measures or on ex vivo expanded CTL clones. We here describe a novel application of cytotoxic saporin-conjugated tetramers to kill antigen-specific T-cells without significant off-target effects. The relative efficacy of distinct antiviral CD8+ T-...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1371/journal.pone.0184496

Authors


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Clarendon Fund More from this funder
National Institute for Health Research More from this funder
Publisher:
Public Library of Science Publisher's website
Journal:
PLoS one Journal website
Volume:
12
Issue:
10
Pages:
e0184496
Publication date:
2017-10-01
Acceptance date:
2017-08-24
DOI:
EISSN:
1932-6203
Pmid:
29020090
Source identifiers:
737238
Language:
English
Keywords:
Pubs id:
pubs:737238
UUID:
uuid:6f4eda91-0a80-48b9-af0c-7a6738903dae
Local pid:
pubs:737238
Deposit date:
2017-10-26

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