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Drug-cured experimental Trypanosoma cruzi infections confer long-lasting and cross-strain protection

Abstract:

Background The long term and complex nature of Chagas disease in humans has restricted studies on vaccine feasibility. Animal models also have limitations due to technical difficulties in monitoring the extremely low parasite burden that is characteristic of chronic stage infections. Advances in imaging technology offer alternative approaches that circumvent these problems. Here, we describe the use of highly sensitive whole body in vivo imaging to assess the efficacy of recombinant viral vec...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1371/journal.pntd.0007717

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Role:
Author
ORCID:
0000-0003-3400-6243
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Medical Research Council More from this funder
Publisher:
Public Library of Science Publisher's website
Journal:
PLoS Neglected Tropical Diseases Journal website
Volume:
14
Issue:
4
Article number:
e0007717
Publication date:
2020-04-17
Acceptance date:
2020-02-11
DOI:
EISSN:
1935-2735
ISSN:
1935-2727
Language:
English
Keywords:
Pubs id:
1101343
Local pid:
pubs:1101343
Deposit date:
2020-04-24

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