Journal article
The group II metabotropic glutamate receptor agonist LY354740 and the D2 receptor antagonist haloperidol reduce locomotor hyperactivity but fail to rescue spatial working memory in GluA1 knockout mice.
- Abstract:
-
Group II metabotropic glutamate receptor agonists have been suggested as potential anti-psychotics, at least in part, based on the observation that the agonist LY354740 appeared to rescue the cognitive deficits caused by non-competitive N-methyl-d-aspartate receptor (NMDAR) antagonists, including spatial working memory deficits in rodents. Here, we tested the ability of LY354740 to rescue spatial working memory performance in mice that lack the GluA1 subunit of the AMPA glutamate receptor, en...
Expand abstract
- Publication status:
- Published
- Peer review status:
- Peer reviewed
Actions
Funding
Bibliographic Details
- Publisher:
- Wiley Publisher's website
- Journal:
- European Journal of Neuroscience Journal website
- Volume:
- 45
- Issue:
- 7
- Pages:
- 912-921
- Publication date:
- 2017-03-04
- Acceptance date:
- 2017-02-07
- DOI:
- EISSN:
-
1460-9568
- ISSN:
-
0953-816X
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:679803
- UUID:
-
uuid:6dfed18a-313a-47bc-8ecf-8fec9e8fed89
- Local pid:
- pubs:679803
- Deposit date:
- 2017-05-01
Terms of use
- Copyright holder:
- © 2017 The Authors
- Copyright date:
- 2017
- Notes:
- This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
- Licence:
- CC Attribution (CC BY)
Metrics
If you are the owner of this record, you can report an update to it here: Report update to this record