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Thesis

Functional study of waist-hip ratio associated loci and the WARS2 gene as modulators of fat distribution.

Abstract:

Waist-hip ratio (WHR) is a risk factor for diabetes and cardiovascular disease. Genome-wide association studies identified 346 loci linked to increased WHR adjusted for Body Mass Index (WHRadjBMI) (Shungin et al., 2015; Pulit et al., 2018). To elucidate the genetic underpinning of WHRadjBMI, I aimed to identify causal SNPs in 4 of these loci and test the tryptophanyl-tRNA synthetase 2 (WARS2) gene, previously shown to severely affect adipose mass, as modulators of fat distribution and brow...

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Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Oxford college:
Wolfson College
Role:
Author

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Oxford college:
Wolfson College
Role:
Supervisor
Oxford college:
Wolfson College
Role:
Supervisor
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
Language:
English
Keywords:
Subjects:
UUID:
uuid:6d47538c-28f5-46dd-a7b9-89fff607a93f
Deposit date:
2020-02-06

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