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The role of plasma microseminoprotein-beta in prostate cancer: an observational nested case-control and Mendelian randomization study in the European prospective investigation into cancer and nutrition

Abstract:

Background Microseminoprotein-beta (MSP), a protein secreted by the prostate epithelium, may have a protective role in the development of prostate cancer. The only previous prospective study found a 2% reduced prostate cancer risk per unit increase in MSP. This work investigates the association of MSP with prostate cancer risk using observational and Mendelian randomization (MR) methods. Patients and methods A nested case–control study was conducted with the European Prospective Investigation...

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Publication status:
Published
Peer review status:
Peer reviewed

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Files:
Publisher copy:
10.1093/annonc/mdz121

Authors


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Division:
MSD
Sub department:
Cancer Epidemiology Unit
Role:
Author
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Division:
MSD
Sub department:
Clinical Trial Service Unit
Role:
Author
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Division:
MSD
Sub department:
Cancer Epidemiology Unit
Role:
Author
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Cancer Research UK More from this funder
Publisher:
Oxford University Press Publisher's website
Journal:
Annals of Oncology Journal website
Volume:
30
Issue:
6
Pages:
983-989
Publication date:
2019-04-08
Acceptance date:
2019-03-21
DOI:
EISSN:
1569-8041
ISSN:
0923-7534
Pmid:
31089709
Language:
English
Keywords:
Pubs id:
984228
Local pid:
pubs:984228
Deposit date:
2020-06-19

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