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Journal article

RSPO3 impacts body fat distribution and regulates adipose cell biology in vitro

Abstract:

Fat distribution is an independent cardiometabolic risk factor. However, its molecular and cellular underpinnings remain obscure. Here we demonstrate that two independent GWAS signals at RSPO3, which are associated with increased body mass index-adjusted waist-to-hip ratio, act to specifically increase RSPO3 expression in subcutaneous adipocytes. These variants are also associated with reduced lower-body fat, enlarged gluteal adipocytes and insulin resistance. Based on human cellular studies ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/s41467-020-16592-z

Authors


More by this author
Division:
MSD
Department:
RDM
Sub department:
OCDEM
Oxford college:
Wolfson College
Role:
Author
More by this author
Division:
MSD
Department:
RDM
Sub department:
OCDEM
Oxford college:
Wolfson College
Role:
Author, Author
More by this author
Division:
MSD
Department:
RDM
Sub department:
OCDEM
Oxford college:
Wolfson College
Role:
Author
More by this author
Division:
MSD
Department:
RDM
Sub department:
OCDEM
Oxford college:
Wolfson College
Role:
Author
More by this author
Division:
MSD
Department:
RDM
Sub department:
OCDEM
Oxford college:
Wolfson College
Role:
Author
Expand authors...
Publisher:
Springer Nature Publisher's website
Journal:
Nature Communications Journal website
Volume:
11
Article number:
2797
Publication date:
2020-06-03
Acceptance date:
2020-05-07
DOI:
ISSN:
2041-1723
Language:
English
Pubs id:
1103906
Local pid:
pubs:1103906
Deposit date:
2020-05-11

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