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Viral vectors expressing group B meningococcal outer membrane proteins induce strong antibody responses but fail to induce functional bactericidal activity

Abstract:

Objective

Adenoviral vectored vaccines, with the appropriate gene insert, induce cellular and antibody responses against viruses, parasites and intracellular pathogens such as Mycobacterium tuberculosis. Here we explored their capacity to induce functional antibody responses to meningococcal transmembrane outer membrane proteins.

Methods

Vectors expressing porin A and ferric enterobactin receptor A antigens were generated, and their immunogenic... Expand abstract
Publication status:
In press
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.jinf.2022.02.032

Authors


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Publisher:
Elsevier Publisher's website
Journal:
Journal of Infection Journal website
Publication date:
2022-03-01
Acceptance date:
2022-02-27
DOI:
EISSN:
1532-2742
ISSN:
0163-4453
Pmid:
35245584
Language:
English
Keywords:
Pubs id:
1243402
Local pid:
pubs:1243402
Deposit date:
2022-03-28

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