Thesis icon

Thesis

Single-cell characterisation of T lymphocyte immune responses in spondyloarthropathy

Abstract:

The spondyloarthropathies (SpA) are a collection of inflammatory disorders of undetermined etiology affecting the joints and connective tissues, however existing evidence suggests a role for the microbiome, CD4 and CD8 T cells in disease pathogenesis.

A CD154 activation based functional assay was first used to quantify and characterise CD4+ memory T cell populations reactive to a panel of 13 microbes found at mucosal barrier sites, predominantly gut bacteria. Peripheral blood monon...

Expand abstract

Actions


Authors


More by this author
Division:
MSD
Department:
NDORMS
Oxford college:
St Hilda's College
Role:
Author

Contributors

Role:
Supervisor
Role:
Supervisor
Role:
Examiner
Role:
Examiner
More from this funder
Programme:
Kennedy Institute Prize Studentship
Funding agency for:
Penkava, F
Grant:
AZR00280 - HF00.05
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
Language:
English
Keywords:
Subjects:
Deposit date:
2021-09-09

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP