Journal article icon

Journal article

Sex-differential impact of human cytomegalovirus infection on in vitro reactivity to toll-like receptor 2, 4 and 7/8 stimulation in Gambian infants

Abstract:

Human cytomegalovirus (HCMV) infection rates approach 100% by the first year of life in low-income countries. It is not known if this drives changes to innate immunity in early life and thereby altered immune reactivity to infections and vaccines. Given the panoply of sex differences in immunity, it is feasible that any immunological effects of HCMV would differ in males and females. We analysed ex vivo innate cytokine responses to a panel of toll-like receptor (TLR) ligands in 108 nine-month...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

Actions


Access Document


Files:
Publisher copy:
10.3390/vaccines8030407

Authors


More by this author
Role:
Author
ORCID:
0000-0002-2610-5017
Expand authors...
Medical Research Council More from this funder
Publisher:
MDPI Publisher's website
Journal:
Vaccines Journal website
Volume:
8
Issue:
3
Article number:
407
Publication date:
2020-07-22
Acceptance date:
2020-07-20
DOI:
EISSN:
2076-393X
Pmid:
32707906
Language:
English
Keywords:
Pubs id:
1123257
Local pid:
pubs:1123257
Deposit date:
2020-08-31

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP