Thesis
Mutational analysis of isoform selectivity and conformational equilibria in protein kinase inhibition
- Abstract:
-
Deregulation of protein kinases is associated with many diseases making them important targets for therapeutic intervention. Kinases can switch between active and inactive conformations that can be targeted by type 1 or type 2 inhibitors respectively. One of the most relevant conformational switches is the ‘in’ and ‘out’ movement of the ATP/Mg2+ binding motif DFG. Factors modulating the conformational equilibria such as the residue environment of regulatory motifs remain poorly understood ...
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Authors
Contributors
+ Knapp, S
Division:
MSD
Department:
NDM
Role:
Supervisor
+ Deane, C
Division:
MSD
Department:
NDM
Role:
Supervisor
+ Jacob, S
Division:
MSD
Department:
NDM
Role:
Supervisor
+ Moebitz, H
Division:
MSD
Department:
NDM
Role:
Supervisor
Funding
Bibliographic Details
- Publication date:
- 2015
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- Oxford University, UK
Item Description
- Language:
- English
- Keywords:
- Subjects:
- UUID:
-
uuid:6a2a12f6-4787-4398-81c0-fa5d6afe96f0
- Local pid:
- ora:9644
- Deposit date:
- 2015-01-05
Terms of use
- Copyright holder:
- Alexander, L
- Copyright date:
- 2014
- Notes:
- This thesis is not currently available in ORA.
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