Journal article
Horizontally acquired AT-rich genes in Escherichia coli cause toxicity by sequestering RNA polymerase
- Abstract:
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Horizontal gene transfer permits rapid dissemination of genetic elements between individuals in bacterial populations. Transmitted DNA sequences may encode favourable traits. However, if the acquired DNA has an atypical base composition, it can reduce host fitness. Consequently, bacteria have evolved strategies to minimize the harmful effects of foreign genes. Most notably, xenogeneic silencing proteins bind incoming DNA that has a higher AT content than the host genome. An enduring question ...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Accepted Manuscript
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(pdf, 813.8KB)
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- Publisher copy:
- 10.1038/nmicrobiol.2016.249
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Authors
Funding
+ Biotechnology and Biological Sciences Research Council
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Funding agency for:
Stracy, M
+ Biotechnology and Biological Sciences Research Council
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Funding agency for:
Kapanidis, AN
+ Wellcome Trust
More from this funder
Grant:
Career Development Fellowship (WT085092MA) awarded to D.C.G.
Bibliographic Details
- Publisher:
- Springer Nature Publisher's website
- Journal:
- Nature Microbiology Journal website
- Volume:
- 2
- Issue:
- 3
- Pages:
- Article: 16249
- Publication date:
- 2017-01-09
- Acceptance date:
- 2016-10-21
- DOI:
- ISSN:
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2058-5276
- Pubs id:
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pubs:670917
- URN:
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uri:69f8e4b2-8941-4b5e-a974-21ee36c22add
- UUID:
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uuid:69f8e4b2-8941-4b5e-a974-21ee36c22add
- Local pid:
- pubs:670917
Item Description
- Language:
- English
Terms of use
- Copyright holder:
- Lamberte et al.
- Copyright date:
- 2017
- Notes:
-
This is the accepted manuscript version of the article. The final version is available online from Springer Nature at: https://doi.org/10.1038/nmicrobiol.2016.249
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