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Journal article : Review

Studying human nociceptors: from fundamentals to clinic

Abstract:

Chronic pain affects one in five of the general population and is the third most important cause of disability-adjusted life-years globally. Unfortunately, treatment remains inadequate due to poor efficacy and tolerability. There has been a failure in translating promising preclinical drug targets into clinic use. This reflects challenges across the whole drug development pathway, from preclinical models to trial design. Nociceptors remain an attractive therapeutic target: their sensitization...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1093/brain/awab048

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Clinical Neurosciences
Oxford college:
Harris Manchester College
Role:
Author
ORCID:
0000-0002-0708-7335
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Institution:
University of Oxford
Division:
MSD
Department:
Clinical Neurosciences
Oxford college:
Green Templeton College
Role:
Author
ORCID:
0000-0002-6787-6889
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Clinical Neurosciences
Role:
Author
ORCID:
0000-0002-9559-8839
More by this author
Role:
Author
ORCID:
0000-0002-6857-9464
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Wellcome Pain Consortium More from this funder
Publisher:
Oxford University Press Publisher's website
Journal:
Brain Journal website
Volume:
144
Issue:
5
Pages:
1312-1335
Place of publication:
England
Publication date:
2021-06-21
Acceptance date:
2020-12-08
DOI:
EISSN:
1460-2156
ISSN:
0006-8950
Pmid:
34128530
Language:
English
Keywords:
Subtype:
Review
Pubs id:
1182068
Local pid:
pubs:1182068
Deposit date:
2022-01-29

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