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Thesis

Studies of antibody conformational ensembles towards better understanding of structure and function

Abstract:

In this thesis, we examine relationships between structural, biophysical and dynamic properties of antibodies. First, we investigate determinants of the binding rates of antibodies, showing that the flexibility of the third complementarity-determining region of the heavy chain (CDR-H3) and the epitope are predictors of this, while analysis of static structures does not yield information on binding rates. We also show that consideration of the conformational ensemble of an antibody gives an en...

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Institution:
University of Oxford
Division:
MSD
Department:
Doctoral Training Centre - MSD
Research group:
Kavli Institute
Oxford college:
Merton College
Role:
Author
ORCID:
0000-0002-4180-4940

Contributors

Institution:
University of Oxford
Division:
MPLS
Department:
Statistics
Sub department:
Statistics
Role:
Supervisor
ORCID:
0000-0003-1388-2252
Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Sub department:
Biochemistry
Role:
Supervisor
ORCID:
0000-0002-2870-1955
More from this funder
Name:
Wellcome Trust
Funder identifier:
https://ror.org/029chgv08
Funding agency for:
Guloglu, B
Grant:
102164/Z/13/Z
Programme:
Cellular Structural Biology
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
DOI:

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