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Single-molecule and super-resolution imaging of transcription in living bacteria

Abstract:

In vivo single-molecule and super-resolution techniques are transforming our ability to study transcription as it takes place in its native environment in living cells. This review will detail the methods for imaging single molecules in cells, and the data-analysis tools which can be used to extract quantitative information on the spatial organization, mobility, and kinetics of the transcription machinery from these experiments. Furthermore, we will highlight studies which have applied these ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.ymeth.2017.04.001

Authors


More by this author
Institution:
University of Oxford
Division:
MPLS Division
Department:
Physics
Role:
Author
ORCID:
0000-0001-5685-0352
More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Physics
Sub department:
Condensed Matter Physics
Oxford college:
St Cross College
Role:
Author
Publisher:
Elsevier Publisher's website
Journal:
Methods Journal website
Volume:
120
Pages:
103-114
Publication date:
2017-04-13
Acceptance date:
2017-04-05
DOI:
EISSN:
1095-9130
ISSN:
1046-2023
Pmid:
28414097
Language:
English
Keywords:
Pubs id:
pubs:691144
UUID:
uuid:68f81e77-eb6c-43b9-b2e0-af408c1a9582
Local pid:
pubs:691144
Deposit date:
2018-02-27

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