Journal article
Neuregulin 1 type I overexpression is associated with reduced NMDA receptor-mediated synaptic signaling in hippocampal interneurons expressing PV or CCK
- Abstract:
-
Hypofunction of N-methyl-d-aspartate receptors (NMDARs) in inhibitory GABAergic interneurons is implicated in the pathophysiology of schizophrenia (SZ), a heritable disorder with many susceptibility genes. However, it is still unclear how SZ risk genes interfere with NMDAR-mediated synaptic transmission in diverse inhibitory interneuron populations. One putative risk gene is neuregulin 1 (NRG1), which signals via the receptor tyrosine kinase ErbB4, itself a schizophrenia risk gene. The type I...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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Authors
Funding
Biotechnology and Biological Sciences Research Council
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John Fell Fund
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Medical Research Council
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University of Oxford
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Hungarian Academy of Sciences
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Bibliographic Details
- Publisher:
- Society for Neuroscience Publisher's website
- Journal:
- eNeuro Journal website
- Volume:
- 5
- Issue:
- 2
- Pages:
- e0418-17
- Publication date:
- 2018-04-20
- Acceptance date:
- 2018-02-28
- DOI:
- EISSN:
-
2373-2822
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:847107
- UUID:
-
uuid:684bd4af-b386-491b-816f-9af901af5b0a
- Local pid:
- pubs:847107
- Source identifiers:
-
847107
- Deposit date:
- 2018-06-15
Terms of use
- Copyright holder:
- Kotzadimitriou et al
- Copyright date:
- 2018
- Notes:
- Copyright © 2018 Kotzadimitriou et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.
- Licence:
- CC Attribution (CC BY)
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