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Journal article

Metabolomic consequences of genetic inhibition of PCSK9 compared with statin treatment

Abstract:

Background

Both statins and PCSK9 inhibitors lower blood low-density lipoprotein cholesterol (LDL C) levels to reduce risk of cardiovascular events. To assess potential differences between metabolic effects of these two lipid-lowering therapies, we performed detailed lipid and metabolite profiling ¬of a large randomized statin trial and compared the results with the effects of genetic inhibition of PCSK9, acting as a naturally occurring trial.

Methods

228 circulat...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1161/CIRCULATIONAHA.118.034942

Authors


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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Nuffield Dept of Population Health
Sub department:
Clinical Trial Service Unit
Role:
Author
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Funding agency for:
Holmes, MV
Grant:
FS/18/23/33512
More from this funder
Funding agency for:
Holmes, MV
Grant:
FS/18/23/33512
More from this funder
Funding agency for:
Holmes, MV
Grant:
FS/18/23/33512
Academy of Finland More from this funder
University of Oulu More from this funder
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Publisher:
American Heart Association Publisher's website
Journal:
Circulation Journal website
Volume:
138
Issue:
22
Publication date:
2018-08-15
Acceptance date:
2018-07-17
DOI:
EISSN:
1524-4539
ISSN:
0009-7322
Source identifiers:
926679
Keywords:
Pubs id:
pubs:926679
UUID:
uuid:66fc748e-32ea-467d-aedb-260991c63fbc
Local pid:
pubs:926679
Deposit date:
2018-10-11

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