Thesis
The HMGB1-CXCL12 heterocomplex and its interaction with CXCR4 as a target for tissue repair
- Abstract:
-
Reduced High Mobility Group Box 1 (HMGB1) protein binds to CXC Ligand 12 (CXCL12), signals through CXC Receptor 4 (CXCR4) to promote tissue regeneration and accelerates repair by transitioning stem and progenitor cells to GAlert. Therefore, administration of fully reduced HMGB1 (FR-HMGB1) could prove beneficial in clinical practice. However, local conversion of FR-HMGB1 to the disulfide form (DS-HMGB1) may result in deleterious inflammation through signalling via Toll-Like Receptors 2 and ...
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Authors
Contributors
+ Yue, W
Division:
MSD
Department:
NDM
Sub department:
Structural Genomics Consortium
Role:
Contributor
+ Redfield, C
Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Role:
Contributor
+ Duerr, K
Division:
MSD
Department:
NDM
Sub department:
Structural Genomics Consortium
Role:
Supervisor
+ Burgess Brown, N
Division:
MSD
Department:
Biochemistry
Role:
Supervisor
+ Nanchahal, J
Division:
MSD
Department:
NDORMS
Sub department:
Kennedy Institute for Rheumatology
Role:
Supervisor
ORCID:
0000-0002-9579-9411
Funding
+ Kennedy Trust for Rheumatology Research
More from this funder
Funder identifier:
http://dx.doi.org/10.13039/100016580
Grant:
AZR00540
Bibliographic Details
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- University of Oxford
Item Description
- Language:
- English
- Keywords:
- Subjects:
- Deposit date:
- 2021-04-08
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Terms of use
- Copyright holder:
- Vinals Guitart, Alvaro
- Copyright date:
- 2021
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