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Thesis

The HMGB1-CXCL12 heterocomplex and its interaction with CXCR4 as a target for tissue repair

Abstract:

Reduced High Mobility Group Box 1 (HMGB1) protein binds to CXC Ligand 12 (CXCL12), signals through CXC Receptor 4 (CXCR4) to promote tissue regeneration and accelerates repair by transitioning stem and progenitor cells to GAlert. Therefore, administration of fully reduced HMGB1 (FR-HMGB1) could prove beneficial in clinical practice. However, local conversion of FR-HMGB1 to the disulfide form (DS-HMGB1) may result in deleterious inflammation through signalling via Toll-Like Receptors 2 and ...

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Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Sub department:
Kennedy Institute for Rheumatology
Oxford college:
St Hilda's College
Role:
Author

Contributors

Division:
MSD
Department:
NDM
Sub department:
Structural Genomics Consortium
Role:
Contributor
Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Role:
Contributor
Division:
MSD
Department:
NDM
Sub department:
Structural Genomics Consortium
Role:
Supervisor
Division:
MSD
Department:
Biochemistry
Role:
Supervisor
Division:
MSD
Department:
NDORMS
Sub department:
Kennedy Institute for Rheumatology
Role:
Supervisor
ORCID:
0000-0002-9579-9411
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Programme:
Full scholarship for the purpose of performing a DPhil
Grant:
AZR00540
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
Language:
English
Keywords:
Subjects:
Deposit date:
2021-04-08

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