Journal article
Triglyceride lowering LPL alleles combined with LDL-C lowering alleles are associated with an additively improved lipoprotein profile
- Abstract:
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Aim and objectives: In Mendelian Randomization studies, triglyceride (TG) lowering lipoprotein lipase (LPL) alleles and LDL-cholesterol (LDL-C) lowering alleles have shown additional beneficial associations with cardiovascular disease (CVD) risk. We aimed to provide further insight in this observation by applying Mendelian Randomization analyses of genetically influenced TG and LDL-C levels on plasma metabolomic profiles.
Methods: We quantified ove...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Version of record, 6.5MB)
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- Publisher copy:
- 10.1016/j.atherosclerosis.2021.04.015
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Authors
Funding
John Fell Fund
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Bibliographic Details
- Publisher:
- Elsevier Publisher's website
- Journal:
- Atherosclerosis Journal website
- Volume:
- 328
- Pages:
- 144-152
- Publication date:
- 2021-05-09
- Acceptance date:
- 2021-04-29
- DOI:
- ISSN:
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0021-9150
Item Description
- Language:
- English
- Keywords:
- Pubs id:
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1173979
- Local pid:
- pubs:1173979
- Deposit date:
- 2021-04-29
Terms of use
- Copyright holder:
- Ibi et al.
- Copyright date:
- 2021
- Rights statement:
- © 2021 The Author(s). Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
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