Journal article
Anti-diabetic action of all-trans retinoic acid and the orphan G protein coupled receptor GPRC5C in pancreatic β-cells
- Abstract:
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Pancreatic islets express high levels of the orphan G-protein coupled receptor C5C (GPRC5C), the function of which remains to be established. Here we have examined the role of GPRC5C in the regulation of insulin secretion and β-cell survival and proliferation using human and mouse pancreatic islets. The expression of GPRC5C was analysed by RNA-sequencing, qPCR, western blotting and confocal microscopy. Insulin secretion and cell viability were determined by RIA and MTS assays, respectively. G...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
-
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(Accepted manuscript, pdf, 574.8KB)
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(Accepted manuscript, pdf, 7.8MB)
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- Publisher copy:
- 10.1507/endocrj.ej16-0338
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Authors
Funding
+ Wellcome Trust
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Funding agency for:
Rorsman, P
Grant:
Senior Investigator Award WT095531/Z/11/Z
Diabetes Wellness Network Sweden
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Swedish Science Council
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European Foundation for the Study of Diabetes
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Swedish Diabetes Society
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Bibliographic Details
- Publisher:
- Japan Endocrine Society Publisher's website
- Journal:
- Endocrine Journal Journal website
- Volume:
- 64
- Issue:
- 3
- Pages:
- 325-338
- Publication date:
- 2017-03-31
- Acceptance date:
- 2016-11-21
- DOI:
- EISSN:
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1348-4540
- ISSN:
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0918-8959
- Pmid:
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28228611
- Source identifiers:
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682025
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:682025
- UUID:
-
uuid:661e42d2-01fe-4333-84ad-9a01ea1ad00d
- Local pid:
- pubs:682025
- Deposit date:
- 2017-10-16
Terms of use
- Copyright holder:
- Japan Endocrine Society
- Copyright date:
- 2017
- Notes:
- © The Japan Endocrine Society. This is the accepted manuscript version of the article. The final version is available online from the Japan Endocrine Society at: [10.1507/endocrj.ej16-0338]
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