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Anti-diabetic action of all-trans retinoic acid and the orphan G protein coupled receptor GPRC5C in pancreatic β-cells

Abstract:

Pancreatic islets express high levels of the orphan G-protein coupled receptor C5C (GPRC5C), the function of which remains to be established. Here we have examined the role of GPRC5C in the regulation of insulin secretion and β-cell survival and proliferation using human and mouse pancreatic islets. The expression of GPRC5C was analysed by RNA-sequencing, qPCR, western blotting and confocal microscopy. Insulin secretion and cell viability were determined by RIA and MTS assays, respectively. G...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1507/endocrj.ej16-0338

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM; OCDEM
Role:
Author
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Funding agency for:
Rorsman, P
Grant:
Senior Investigator Award WT095531/Z/11/Z
Diabetes Wellness Network Sweden More from this funder
Swedish Science Council More from this funder
European Foundation for the Study of Diabetes More from this funder
Swedish Diabetes Society More from this funder
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Publisher:
Japan Endocrine Society Publisher's website
Journal:
Endocrine Journal Journal website
Volume:
64
Issue:
3
Pages:
325-338
Publication date:
2017-03-31
Acceptance date:
2016-11-21
DOI:
EISSN:
1348-4540
ISSN:
0918-8959
Pmid:
28228611
Source identifiers:
682025

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