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At least two Fc Neu5Gc residues of monoclonal antibodies are required for binding to anti-Neu5Gc antibody

Abstract:

Two non-human glycan epitopes, galactose-Į-1,3-galactose (Į-gal) and Neu5Gc-Į-2-6-galactose (Neu5Gc) have been shown to be antigenic when attached to Fab oligosaccharides of monoclonal antibodies (mAbs) , while Į-gal attached to Fc glycans were not. However, the antigenicity of Neu5Gc on the Fc glycans remains unclear in the context that most mAbs carry only Fc glycans. After studying two clinical mAbs carrying significant amounts of Fc Neu5Gc, we show that their binding activity with anti-Ne...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/srep20029

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Publisher:
Nature Publishing Group Publisher's website
Journal:
Scientific Reports Journal website
Volume:
6
Article number:
20029
Publication date:
2016-01-29
Acceptance date:
2015-12-14
DOI:
ISSN:
2045-2322
Source identifiers:
579985
Pubs id:
pubs:579985
UUID:
uuid:65885792-2405-4e01-94ea-413712e27dc3
Local pid:
pubs:579985
Deposit date:
2015-12-14

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