Journal article
At least two Fc Neu5Gc residues of monoclonal antibodies are required for binding to anti-Neu5Gc antibody
- Abstract:
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Two non-human glycan epitopes, galactose-Į-1,3-galactose (Į-gal) and Neu5Gc-Į-2-6-galactose (Neu5Gc) have been shown to be antigenic when attached to Fab oligosaccharides of monoclonal antibodies (mAbs) , while Į-gal attached to Fc glycans were not. However, the antigenicity of Neu5Gc on the Fc glycans remains unclear in the context that most mAbs carry only Fc glycans. After studying two clinical mAbs carrying significant amounts of Fc Neu5Gc, we show that their binding activity with anti-Ne...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Version of record, pdf, 116.3KB)
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(Version of record, pdf, 1.5MB)
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- Publisher copy:
- 10.1038/srep20029
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Funding
Bibliographic Details
- Publisher:
- Nature Publishing Group Publisher's website
- Journal:
- Scientific Reports Journal website
- Volume:
- 6
- Article number:
- 20029
- Publication date:
- 2016-01-29
- Acceptance date:
- 2015-12-14
- DOI:
- ISSN:
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2045-2322
Item Description
- Pubs id:
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pubs:579985
- UUID:
-
uuid:65885792-2405-4e01-94ea-413712e27dc3
- Local pid:
- pubs:579985
- Source identifiers:
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579985
- Deposit date:
- 2015-12-14
Terms of use
- Copyright holder:
- Yu et al
- Copyright date:
- 2016
- Notes:
- This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. Note: an erratum exists for this article, originally published and available at: http://dx.doi.org/10.1038/srep46385
- Licence:
- CC Attribution (CC BY)
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