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Thesis

Characterising the cell biology of leukemic stem cells in acute myeloid leukemia.

Abstract:

Acute Myeloid leukemia (AML) is an aggressive haematological malignancy that mainly affects the elderly. Relapse is common and is thought to be due to the presence of chemotherapy resistant leukemic stem cells (LSC). Within the CD34+ disease (>5% of the blast cells expressing CD34) , two subtypes have been identified; an LMPP/GMPlike expanded type and a MPP/CMP-like expanded type, the former is the most common, accounting for around 80% of CD34+ AML. Both the GMP-like and LMPPlike expan...

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Institution:
University of Oxford
Oxford college:
Green Templeton College
Department:
Medical Sciences Division - Clinical Medicine,Nuffield Department of
Role:
Author

Contributors

Role:
Supervisor
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Funding agency for:
Terri Victoria Cornforth
Publication date:
2013
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
Oxford University, UK
URN:
uuid:654b2176-fd50-427e-86f2-74e928054bef
Local pid:
ora:8690

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