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IRF5 guides monocytes toward an inflammatory CD11c+ macrophage phenotype and promotes intestinal inflammation

Abstract:

Mononuclear phagocytes (MNPs) are vital for maintaining intestinal homeostasis but, in response to acute microbial stimulation, can also trigger immunopathology, accelerating recruitment of Ly6Chi monocytes to the gut. The regulators that control monocyte tissue adaptation in the gut remain poorly understood. Interferon regulatory factor 5 (IRF5) is a transcription factor previously shown to play a key role in maintaining the inflammatory phenotype of macrophages. Here, we investigate the imp...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1126/sciimmunol.aax6085

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Sub department:
Kennedy Institute for Rheumatology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Sub department:
Kennedy Institute for Rheumatology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Sub department:
Kennedy Institute for Rheumatology
Role:
Author
ORCID:
0000-0002-9045-6348
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Sub department:
Kennedy Institute for Rheumatology
Role:
Author
ORCID:
0000-0003-4116-1276
More by this author
Role:
Author
ORCID:
0000-0001-8679-9666
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Publisher:
American Association for the Advancement of Science Publisher's website
Journal:
Science Immunology Journal website
Volume:
5
Issue:
47
Article number:
eaax6085
Place of publication:
United States
Publication date:
2020-05-22
Acceptance date:
2020-04-02
DOI:
EISSN:
2470-9468
Pmid:
32444476
Language:
English
Keywords:
Pubs id:
1106557
Local pid:
pubs:1106557
Deposit date:
2020-05-28

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