Journal article
Glycine receptor autoantibodies disrupt inhibitory neurotransmission
- Abstract:
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Chloride-permeable glycine receptors have an important role in fast inhibitory neurotransmission in the spinal cord and brainstem. Human immunoglobulin G (IgG) autoantibodies to glycine receptors are found in a substantial proportion of patients with progressive encephalomyelitis with rigidity and myoclonus, and less frequently in other variants of stiff person syndrome. Demonstrating a pathogenic role of glycine receptor autoantibodies would help justify the use of immunomodulatory therapies...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Version of record, 970.8KB)
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- Publisher copy:
- 10.1093/brain/awz297
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Authors
Funding
Medical Research Council
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Bibliographic Details
- Publisher:
- Oxford University Press Publisher's website
- Journal:
- Brain Journal website
- Volume:
- 142
- Issue:
- 11
- Pages:
- 3398-3410
- Publication date:
- 2019-10-08
- Acceptance date:
- 2019-08-07
- DOI:
- EISSN:
-
1460-2156
- ISSN:
-
0006-8950
- Pmid:
-
31591639
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
1065291
- Local pid:
- pubs:1065291
- Deposit date:
- 2020-05-30
Terms of use
- Copyright holder:
- Crisp et al.
- Copyright date:
- 2019
- Rights statement:
- © The Author(s) (2019). Published by Oxford University Press on behalf of the Guarantors of Brain. This is an Open Access article distributed under the terms of the Creative Commons Attribution License
- Licence:
- CC Attribution (CC BY)
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