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Journal article

Glycine receptor autoantibodies disrupt inhibitory neurotransmission

Abstract:

Chloride-permeable glycine receptors have an important role in fast inhibitory neurotransmission in the spinal cord and brainstem. Human immunoglobulin G (IgG) autoantibodies to glycine receptors are found in a substantial proportion of patients with progressive encephalomyelitis with rigidity and myoclonus, and less frequently in other variants of stiff person syndrome. Demonstrating a pathogenic role of glycine receptor autoantibodies would help justify the use of immunomodulatory therapies...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1093/brain/awz297

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Clinical Neurosciences
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Clinical Neurosciences
Oxford college:
St Hilda's College
Role:
Author
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Publisher:
Oxford University Press Publisher's website
Journal:
Brain Journal website
Volume:
142
Issue:
11
Pages:
3398-3410
Publication date:
2019-10-08
Acceptance date:
2019-08-07
DOI:
EISSN:
1460-2156
ISSN:
0006-8950
Pmid:
31591639
Language:
English
Keywords:
Pubs id:
1065291
Local pid:
pubs:1065291
Deposit date:
2020-05-30

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