Thesis
Tissue expression and functional insights into HIF prolyl hydroxylase domain enzymes
- Abstract:
-
This research programme investigated the expression of prolyl hydroxylase (PHD) proteins in rodent tissues. The importance of PHD enzymes lies in their ability to render oxygen sensitivity to Hypoxia inducible factor (HIF), the principal mediator of intracellular oxygen homeostasis. The first part of this study focused on developing and validating anti-sera capable of detecting PHD proteins in rodent tissues. With these reagents, it was possible to assess the relative expression of each PH...
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Funding
Bibliographic Details
- Publication date:
- 2013
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- University of Oxford
Item Description
- Language:
- English
- Keywords:
- Subjects:
- UUID:
-
uuid:6330e4d5-0802-427b-a7b3-8895d94e02f2
- Local pid:
- ora:10460
- Deposit date:
- 2015-03-06
Terms of use
- Copyright holder:
- Dr J.B.Wijeyekoon
- Copyright date:
- 2014
- Notes:
- This thesis is not currently available via ORA.
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