Journal article
Blocking variant surface glycoprotein synthesis alters endoplasmic reticulum exit sites/Golgi homeostasis in Trypanosoma brucei
- Abstract:
-
The predominant secretory cargo of bloodstream form Trypanosoma brucei is variant surface glycoprotein (VSG), comprising ~10% total protein and forming a dense protective layer. Blocking VSG translation using Morpholino oligonucleotides triggered a precise pre-cytokinesis arrest. We investigated the effect of blocking VSG synthesis on the secretory pathway. The number of Golgi decreased, particularly in post-mitotic cells, from 3.5 ± 0.6 to 2.0 ± 0.04 per cell. Similarly, the number of endopl...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Version of record, pdf, 32.7MB)
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- Publisher copy:
- 10.1111/tra.12561
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Authors
Funding
Bibliographic Details
- Publisher:
- Wiley Publisher's website
- Journal:
- Traffic Journal website
- Volume:
- 19
- Issue:
- 6
- Pages:
- 391-405
- Publication date:
- 2018-04-06
- Acceptance date:
- 2018-03-08
- DOI:
- EISSN:
-
1600-0854
- ISSN:
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1398-9219
- Pmid:
-
29533496
- Source identifiers:
-
828989
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:828989
- UUID:
-
uuid:62d8ad59-827a-41ed-881b-a0615e66f770
- Local pid:
- pubs:828989
- Deposit date:
- 2018-05-11
Terms of use
- Copyright holder:
- © 2018 Ooi, et al Traffic published by John Wiley and Sons Ltd
- Copyright date:
- 2018
- Notes:
- This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
- Licence:
- CC Attribution (CC BY)
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