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Biowire model of interstitial and focal cardiac fibrosis

Abstract:

Myocardial fibrosis is a severe global health problem due to its prevalence in all forms of cardiac diseases and direct role in causing heart failure. The discovery of efficient antifibrotic compounds has been hampered due to the lack of a physiologically relevant disease model. Herein, we present a disease model of human myocardial fibrosis and use it to establish a compound screening system. In the Biowire II platform, cardiac tissues are suspended between a pair of poly(octamethylene malea...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1021/acscentsci.9b00052

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Publisher:
American Chemical Society Publisher's website
Journal:
ACS Central Science Journal website
Volume:
5
Issue:
7
Pages:
1146-1158
Publication date:
2019-06-04
DOI:
EISSN:
2374-7951
ISSN:
2374-7943
Source identifiers:
1022804
Keywords:
Pubs id:
pubs:1022804
UUID:
uuid:620c76e0-0304-4869-93ab-08423e388dea
Local pid:
pubs:1022804
Deposit date:
2019-07-01

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