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Thesis

Innate immune pathways controlling IL-1beta production and adjuvant-induced T helper 17 cell differentiation

Abstract:

Although adjuvants are critical vaccine components, their modes of action are poorly understood. This has hampered the development of novel adjuvants, and as a result there are very few approved for clinical use. Moreover, none of the clinically-approved adjuvants are able to induce T helper 17 (Th17) CD4+ T cell responses. Th17 cells play important roles in host defense against extracellular bacteria, fungi, and some intracellular pathogens, so understanding how to produce Th17...

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Research group:
Cerundolo Group, Human Immunology Unit
Oxford college:
Magdalen College
Role:
Author

Contributors

Role:
Supervisor
Publication date:
2011
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
Language:
English
Keywords:
Subjects:
UUID:
uuid:610114e6-c1ac-46c2-af4b-4a69659ce8b8
Deposit date:
2016-11-15

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