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Calcium-dependent neuroepithelial contractions expel damaged cells from the developing brain

Abstract:

Both developing and adult organisms need efficient strategies for wound repair. In adult mammals, wounding triggers an inflammatory response that can exacerbate tissue injury and lead to scarring. In contrast, embryonic wounds heal quickly and with minimal inflammation, but how this is achieved remains incompletely understood. Using in vivo imaging in the developing brain of Xenopus laevis, we show that ATP release from damaged cells and subsequent activation of purinergic r...

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Publication status:
Published
Peer review status:
Peer reviewed

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Department:
Pharmacology
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Author
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Department:
Pharmacology
Role:
Author
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Department:
Pharmacology; Corpus Christi
Role:
Author
Journal:
Developmental Cell
Volume:
31
Issue:
5
Pages:
599-613
Publication date:
2014-11-20
Acceptance date:
2014-10-21
DOI:
EISSN:
1878-1551
ISSN:
1534-5807
Language:
English
Keywords:
UUID:
uuid:60a57abf-ab20-4f07-85b2-ceb6aa262612
Deposit date:
2014-12-15

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