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Thesis

Investigating pseudotyped lentiviral vectors for gene delivery to the lung

Abstract:

Recombinant lentiviral vectors (LV) are an attractive vehicle for gene delivery to the lung due to their ability to achieve stable, long-term, expression and the opportunity to add glycoprotein pseudotypes for efficient lung cell-targeting. Two LV pseudotypes derived from sialic acid- binding Sendai virus and influenza virus, referred to as F/HN and Rostock respectively, can facilitate efficient in vivo transduction of the murine airway and were compared alongside a new influenza-based pse...

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Institution:
University of Oxford
Division:
MSD
Department:
RDM
Research group:
Gene Medicine
Oxford college:
St Edmund Hall
Role:
Author
ORCID:
0000-0003-2529-2735

Contributors

Institution:
University of Oxford
Division:
MSD
Department:
RDM
Research group:
Gene Medicine
Role:
Supervisor
Institution:
Oxford Biomedica
Role:
Supervisor
More from this funder
Programme:
industrial Collaborative Award in Science and Engineering (iCASE)
Funding agency for:
Munday, RJ
Grant:
H4T00040
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford

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