Thesis
Investigating pseudotyped lentiviral vectors for gene delivery to the lung
- Abstract:
-
Recombinant lentiviral vectors (LV) are an attractive vehicle for gene delivery to the lung due to their ability to achieve stable, long-term, expression and the opportunity to add glycoprotein pseudotypes for efficient lung cell-targeting. Two LV pseudotypes derived from sialic acid- binding Sendai virus and influenza virus, referred to as F/HN and Rostock respectively, can facilitate efficient in vivo transduction of the murine airway and were compared alongside a new influenza-based pse...
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Authors
Contributors
+ Gill, D
Institution:
University of Oxford
Division:
MSD
Department:
RDM
Research group:
Gene Medicine
Role:
Supervisor
+ Mitrophanos, K
Institution:
Oxford Biomedica
Role:
Supervisor
Funding
+ Medical Research Council
More from this funder
Programme:
industrial Collaborative Award in Science and Engineering (iCASE)
Funding agency for:
Munday, RJ
Grant:
H4T00040
Bibliographic Details
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- University of Oxford
Item Description
- Language:
- English
- Keywords:
- Subjects:
- Deposit date:
- 2021-09-15
Related Items
Terms of use
- Copyright holder:
- Munday, RJ
- Copyright date:
- 2021
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