Journal article
The somatostatin-secreting pancreatic δ-cell in health and disease
- Abstract:
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The somatostatin-secreting δ-cells comprise ~5% of the cells of the pancreatic islets. The δ-cells have complex morphology and might interact with many more islet cells than suggested by their low numbers. δ-Cells contain ATP-sensitive potassium channels, which open at low levels of glucose but close when glucose is elevated. This closure initiates membrane depolarization and electrical activity and increased somatostatin secretion. Factors released by neighbouring α-cells or β-cells amplify ...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
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(Accepted manuscript, pdf, 1.0MB)
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- Publisher copy:
- 10.1038/s41574-018-0020-6
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Authors
Funding
Knut and Alice Wallenberg Foundation
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Hartwell Foundation for Biomedical Research
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Swedish Research Council
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Bibliographic Details
- Publisher:
- Nature Publishing Group Publisher's website
- Journal:
- Nature Reviews Endocrinology Journal website
- Volume:
- 14
- Issue:
- 6
- Pages:
- 404–414
- Publication date:
- 2018-05-17
- DOI:
- EISSN:
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1759-5037
- ISSN:
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1759-5029
- Pmid:
-
29773871
- Source identifiers:
-
853649
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:853649
- UUID:
-
uuid:5ef4526a-aa0e-4e7e-a131-a875cc8ef50a
- Local pid:
- pubs:853649
- Deposit date:
- 2018-06-19
Terms of use
- Copyright holder:
- Macmillan Publishers Limited
- Copyright date:
- 2018
- Notes:
- © 2018 Macmillan Publishers Limited, part of Springer Nature. All rights reserved. This is the accepted manuscript version of the article. The final version is available online from Nature Publishing Group at: https://doi.org/10.1038/s41574-018-0020-6
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