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Cortical reorganisation and tinnitus following restricted peripheral deafferentation in the ferret: targeting neural plasticity by optogenetic silencing

Abstract:

Subjective tinnitus is the perception of a sound in the absence of an environmental source, and is thought to derive from maladaptive neuroplasticity that occurs following hearing impairment. However, the underlying structural and functional mechanisms remain unresolved. Our aims were thus to develop a model of trauma-induced tinnitus, and to investigate whether primary auditory cortex played a causal role.

We tested ferrets on a gap-in-noise detection task to assess auditory tempo...

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S72_Bajo
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Type of award:
DPhil
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University of Oxford

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