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Unravelling haematopoietic stem cell dysfunction in isolated Del(5q) myelodysplastic syndromes

Abstract:

Myelodysplastic syndromes (MDS) represent a heterogeneous group of haematological malignancies. A subgroup of MDS patients are characterized by heterozygous deletion of the long arm of chromosome 5, Del(5q), as the only karyotypic abnormality. The commonly deleted region (CDR) on chromosome 5 contains approximately forty-two genes and haploinsufficiency of one or more of these genes is thought to be the basis for Del(5q) MDS pathogenesis.

The 5q deletion originates in the Hemat...

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Institution:
University of Oxford
Oxford college:
St Cross College
Role:
Author

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Role:
Supervisor
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
UUID:
uuid:5eab7859-53fa-4a55-a04c-eecc3ca19a7e
Deposit date:
2016-07-01

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