Thesis
Unravelling haematopoietic stem cell dysfunction in isolated Del(5q) myelodysplastic syndromes
- Abstract:
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Myelodysplastic syndromes (MDS) represent a heterogeneous group of haematological malignancies. A subgroup of MDS patients are characterized by heterozygous deletion of the long arm of chromosome 5, Del(5q), as the only karyotypic abnormality. The commonly deleted region (CDR) on chromosome 5 contains approximately forty-two genes and haploinsufficiency of one or more of these genes is thought to be the basis for Del(5q) MDS pathogenesis.
The 5q deletion originates in the Hemat...
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Funding
Bibliographic Details
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- University of Oxford
Item Description
- UUID:
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uuid:5eab7859-53fa-4a55-a04c-eecc3ca19a7e
- Deposit date:
- 2016-07-01
Terms of use
- Copyright holder:
- Stenson, L; Laura Stenson
- Copyright date:
- 2015
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