Journal article icon

Journal article

Single-cell ATAC and RNA sequencing reveal pre-existing and persistent cells associated with prostate cancer relapse

Abstract:

Prostate cancer is heterogeneous and patients would benefit from methods that stratify those who are likely to respond to systemic therapy. Here, we employ single-cell assays for transposase-accessible chromatin (ATAC) and RNA sequencing in models of early treatment response and resistance to enzalutamide. In doing so, we identify pre-existing and treatment-persistent cell subpopulations that possess regenerative potential when subjected to treatment. We find distinct chromatin landscapes ass...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

Actions


Access Document


Files:
Publisher copy:
10.1038/s41467-021-25624-1

Authors


More by this author
Role:
Author
ORCID:
0000-0001-7559-9853
More by this author
Role:
Author
ORCID:
0000-0003-3718-3464
More by this author
Role:
Author
ORCID:
0000-0002-7558-5635
Publisher:
Springer Nature Publisher's website
Journal:
Nature Communications Journal website
Volume:
12
Issue:
1
Article number:
5307
Publication date:
2021-09-06
Acceptance date:
2021-08-23
DOI:
EISSN:
2041-1723
Language:
English
Keywords:
Pubs id:
1193925
Local pid:
pubs:1193925
Deposit date:
2021-09-07

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP