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Journal article

Deregulated expression of mammalian lncRNA through loss of SPT6 induces R-Loop formation, replication stress, and cellular senescence

Abstract:

Extensive tracts of the mammalian genome that lack protein-coding function are still transcribed into long noncoding RNA. While these lncRNAs are generally short lived, length restricted, and non-polyadenylated, how their expression is distinguished from protein-coding genes remains enigmatic. Surprisingly, depletion of the ubiquitous Pol-II-associated transcription elongation factor SPT6 promotes a redistribution of H3K36me3 histone marks from active protein coding to lncRNA genes, which cor...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.molcel.2018.10.011

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Pathology Dunn School
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Pathology Dunn School
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Pathology Dunn School
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Pathology Dunn School
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Pathology Dunn School
Oxford college:
Wolfson College
Role:
Author
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More from this funder
Funding agency for:
Murphy, S
Grant:
WT106134AIA
More from this funder
Funding agency for:
Proudfoot, N
Grant:
339270
More from this funder
Funding agency for:
Proudfoot, N
Grant:
339270
Publisher:
Elsevier Publisher's website
Journal:
Molecular Cell Journal website
Volume:
72
Issue:
6
Pages:
970-984
Publication date:
2018-11-15
Acceptance date:
2018-10-09
DOI:
EISSN:
1097-4164
ISSN:
1097-2765
Source identifiers:
944576
Keywords:
Pubs id:
pubs:944576
UUID:
uuid:5db56f96-452b-44af-ad05-5b3d17c7e63c
Local pid:
pubs:944576
Deposit date:
2018-11-20

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