Journal article icon

Journal article

Synergistic silencing of α-globin and induction of γ-globin by histone deacetylase inhibitor, vorinostat as a potential therapy for β-thalassaemia

Abstract:

β-Thalassaemia is one of the most common monogenic diseases with no effective cure in the majority of patients. Unbalanced production of α-globin in the presence of defective synthesis of β-globin is the primary mechanism for anaemia in β-thalassaemia. Clinical genetic data accumulated over three decades have clearly demonstrated that direct suppression of α-globin and induction of γ-globin are effective in reducing the globin chain imbalance in erythroid cells hence improving the clinical ou...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

Actions


Access Document


Files:
Publisher copy:
10.1038/s41598-019-48204-2

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
Weatherall Insti. of Molecular Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM
Sub department:
RDM Strategic
Oxford college:
Green Templeton College
Role:
Author
ORCID:
0000-0002-7680-9311
Expand authors...
Publisher:
Nature Research Publisher's website
Journal:
Scientific Reports Journal website
Volume:
9
Issue:
1
Article number:
11649
Publication date:
2019-08-12
Acceptance date:
2019-07-30
DOI:
EISSN:
2045-2322
Pmid:
31406232
Source identifiers:
1046398
Language:
English
Keywords:
Pubs id:
pubs:1046398
UUID:
uuid:5da78a57-9892-4fa0-aeee-fa4dff10d672
Local pid:
pubs:1046398
Deposit date:
2019-10-15

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP