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Journal article

Metabolomics reveals distinct, antibody-independent, molecular signatures of MS, AQP4-antibody and MOG-antibody disease.

Abstract:

The overlapping clinical features of relapsing remitting multiple sclerosis (RRMS), aquaporin-4 (AQP4)-antibody (Ab) neuromyelitis optica spectrum disorder (NMOSD), and myelin oligodendrocyte glycoprotein (MOG)-Ab disease mean that detection of disease specific serum antibodies is the gold standard in diagnostics. However, antibody levels are not prognostic and may become undetectable after treatment or during remission. Therefore, there is still a need to discover antibody-independent biomar...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1186/s40478-017-0495-8

Authors


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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Pharmacology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Pharmacology
Role:
Author
ORCID:
0000-0002-8580-2023
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Pharmacology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Clinical Neurosciences
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS Division
Department:
Chemistry; Organic Chemistry
Oxford college:
Green Templeton College
Role:
Author
ORCID:
0000-0001-5583-6460
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Publisher:
BioMed Central Publisher's website
Journal:
Acta Neuropathologica Communications Journal website
Volume:
5
Issue:
1
Pages:
95
Publication date:
2017-12-01
Acceptance date:
2017-11-13
DOI:
EISSN:
2051-5960
ISSN:
2051-5960
Pmid:
29208041
Source identifiers:
810338
Language:
English
Keywords:
Pubs id:
pubs:810338
UUID:
uuid:5d5f5d2f-792f-471a-9879-e8647ad4ee9c
Local pid:
pubs:810338
Deposit date:
2018-01-02

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