Journal article icon

Journal article

Bone marrow adiposity and multiple myeloma

Abstract:

Multiple Myeloma (MM) is an incurable haematological malignancy and is the second most common blood cancer in adults; it is caused by the clonal expansion of abnormal plasma cells within the bone marrow and characterized by osteolytic bone lesions, bone pain, renal disease, and immunodeficiency. MM cells infiltrate the bone marrow where they hijack the microenvironment to sustain growth and survival. The contribution to this process by resident bone cells is well defined. However, the role of...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

Actions


Access Document


Files:
Publisher copy:
10.1016/j.bone.2018.03.011

Authors


More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Surgical Sciences
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Oxford college:
St Edmund Hall
Role:
Author
ORCID:
0000-0002-1257-5659
European Research Council More from this funder
National Institute for Health Research More from this funder
Publisher:
Elsevier Publisher's website
Journal:
Bone Journal website
Volume:
118
Pages:
42-46
Publication date:
2018-03-13
Acceptance date:
2018-03-12
DOI:
EISSN:
8756-3282
ISSN:
1873-2763
Pmid:
29548987
Source identifiers:
831289
Language:
English
Keywords:
Pubs id:
pubs:831289
UUID:
uuid:5d0ae54e-ec15-4bca-a5b0-2e842cdb6bc8
Local pid:
pubs:831289
Deposit date:
2018-06-29

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP