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Phenotypic evolutionary models in stem cell biology: replacement, quiescence, and variability

Abstract:

Phenotypic evolutionary models have been used with great success in many areas of biology, but thus far have not been applied to the study of stem cells except for investigations of cancer. We develop a framework that allows such modeling techniques to be applied to stem cells more generally. The fundamental modeling structure is the stochastic kinetics of stem cells in their niche and of transit amplifying and fully differentiated cells elsewhere in the organism, with positive and negative f...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1371/journal.pone.0001591

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Institution:
"University of California Santa Cruz, California, USA"
Department:
Center for Biomolecular Science and Engineering,Department of Applied Mathematics and Statistics
Role:
Author
More by this author
Institution:
University of Oxford
Research group:
Mathematical Ecology Research Group
Oxford college:
St Peter's College
Department:
Mathematical,Physical & Life Sciences Division - Zoology
Role:
Author
National Science Foundation (NSF) More from this funder
Royal Society More from this funder
Astor Travel Fund, University of Oxford More from this funder
Publisher:
Public Library of Science Publisher's website
Journal:
PLoS ONE Journal website
Volume:
3
Issue:
2
Pages:
Article: e1591
Publication date:
2008-02-05
DOI:
EISSN:
1932-6203
URN:
uuid:5cca5ef4-5d1f-4741-bc7d-32cb8cd325d3
Local pid:
ora:2841

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